References & Sources  -  October 10, 1998

<Back to Contents

Epstein-Barr deaths tied to faulty protein

A rare, deadly complication of Epstein-Barr virus is caused by a defective immune-system protein.

 

References:

Coffey, A.J., et al. 1998. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nature Genetics 20(October):129.

Sayos, J., et al. 1998. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395(Oct. 1):462.

 

Further Readings:

Cocks, B.G., et al. 1995. A novel receptor involved in T-cell activation. Nature 376:260.

Epstein, M.A., B.G. Achong, and Y.M. Barr. 1964. Virus particles in cultured lymphocytes from Burkitt's lymphoma. Lancet 1:702.

Fackelmann, K.A. 1995. A versatile virus. Science News 147(Feb. 18):104.

Harrington, D.S., D.D. Weisenburger, and D.T. Purtilo. 1987. Malignant lymphoma in the X-linked Lymphoproliferative Syndrome. Cancer 59:1419.

Kieff, E. 1995. Epstein-Barr virus — increasing evidence of a link to carcinoma. New England Journal of Medicine 333(Sept. 14):724.

Liebowitz, D. 1995. Epstein-Barr virus — an old dog with new tricks. New England Journal of Medicine 332(Jan. 5):55.

Sadelain, M., and E. Kieff. 1998. Why commonplace encounters turn to fatal attraction. Nature Genetics 20(October):103.

Sources:

Alison J. Coffey
Sanger Centre
Wellcome Trust Genome Campus
Hinxton, Cambridgeshire CB10 1SA
United Kingdom

David N. Liebowitz
University of Chicago
Kovler Viral Oncology Laboratories
910 East 58th Street
Chicago, IL 60637

Juan Sayos
Harvard Medical School
Beth Israel Deaconess Medical Center
Division of Immunology
Boston, MA 02215

From Science News, Vol. 154, No. 15, October 10, 1998, p. 229.
Copyright Ó 1998 by Science Service.

Back to Table of Contents - 10/10/98