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Making use of mismatched donor marrow

A new bone-marrow transplant method offers greater success in leukemia patients who must receive mismatched donor marrow.

 

References:

Aversa, F. . . . Y. Reisner, et al. 1998. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. New England Journal of Medicine 339(Oct. 22):1186.

 

Further Readings:

Brooks, A.C. 1994. Bone marrow transplants: Upping odds. Science News 146(Dec. 10):391.

Gluckman, E. 1996. The therapeutic potential of fetal and neonatal hematopoietic stem cells. New England Journal of Medicine 335(Dec. 112):1839.

Sasazuki, T., et al. 1998. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. New England Journal of Medicine 339(Oct. 22):1177.

Travis, J. 1997. Human embryonic stem cells found? Science News 152(July 19):36.

 

Sources:

LeeAnn T. Jensen
National Heart, Lung and Blood Institute
6701 Rockledge Drive
Bethesda, MD 20892-7950

Yair Reisner
Weizmann Institute
Department of Immunology
Rehovot, Israel

From Science News, Vol. 154, No. 17, October 24, 1998, p. 261.
Copyright Ó 1998 by Science Service.

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