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A new angle on a blood-cell hormone

The three-dimensional arrangement of two cell-surface molecules with erythroprotein (EPO), which stimulates production of red blood cells, explains why EPO mimics don’t work as well as the real thing.

 

References:

Syed, R.S., et al. 1998. Efficiency of signalling through Cytokine receptors depends critically on receptor orientation. Nature 395(Oct. 1):511.

 

Further Readings:

1996. Honey, I shrank the hormone! Science News 150(Aug. 10):93.

1990. Rescuing red cells to boast blood supply. Science News 137(April 28):268.

Sources:

Rashid S. Syed
Amgen, Inc.
One Amgen Center Drive
Thousand Oaks, CA 91320-1789

From Science News, Vol. 154, No. 17, October 24, 1998, p. 266.
Copyright Ó 1998 by Science Service.

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