References & Sources  -  October 3, 1998

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Brain cell death remains unsolved mystery

New data challenges the theory that abnormal clumps of mutant proteins cause the cell death characteristic of neurodegenerative disorders such as Huntington’s disease.

 

References:

Klement, I.A. . . . H.T. Orr. 1998. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95(Oct. 2).

Saudou, F. . . . M.E. Greenberg, et al. 1998. Huntington acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95(Oct. 2).

 

Further Readings:

Travis, J. 1997. Nuclear buildup may explain brain diseases. Science News 152(Aug. 16):102.

 

Sources:

Michael E. Greenberg
Children’s Hospital
Division of Neuroscience
Enders 260
Boston, MA 02115

Harry T. Orr
University of Minnesota
Institute of Human Genetics
Box 206 UMHC
Minneapolis, MN 55455

Christopher A. Ross
Johns Hopkins Medical Institutions
Baltimore Huntington's Disease Center
600 North Wolfe Street, Meyer 2-181
Baltimore, MD 21287-7281

Frédéric Saudou
Children’s Hospital
Division of Neuroscience
Enders 260
Boston, MA 02115

From Science News, Vol. 154, No. 14, October 3, 1998, p. 215.
Copyright Ó 1998 by Science Service.

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