Chromosomal Fragility
Can unstable segments of DNA explain some cancers?
Common fragile sites on chromosomes are often damaged in tumor cells, suggesting a link between these genetic weak spots and cancer.
References:
Glover, T. 1998. Common fragile sites in man and mouse. Meeting of the American Society of Human Genetics. October. Denver.
Huebner, K. 1998. Chromosome fragility and cancer. Meeting of the American Society of Human Genetics. October. Denver.
LeBeau, M. 1998. FRA3B is late replicating and fails to complete replication: Implications for the mechanism of fragile site induction. Meeting of the American Society of Human Genetics. October. Denver.
Richkind, K.E., et al. 1998. Association between folate sensitive fragile sites and chromosomal break-points in congenital and infant cancer. Meeting of the American Society of Human Genetics. October. Denver.
Smith, D.I. 1998. Common fragile sites and cancer. Meeting of the American Society of Human Genetics. October. Denver.
Further Readings:
Fackelmann, K.A. 1994. Beyond the genome. Science News 146(Nov. 5):298.
Korf, B. 1995. Molecular diagnosis. New England Journal of Medicine 332(June 1):1499.
Lipkin, R. 1995. DNA repair enzyme: A structure revealed. Science News 148(July 8):20.
Travis, J. 1997. Guardians of the genome? Science News 151(June 21):386.
______. 1995. When CAG spells trouble. Science News 147(June 10):360.
Sources:
Thomas W. Glover
University of Michigan
Department of Human Genetics
4708 MedSci II
Box 0618
Ann Arbor, MI 48109Kay Huebner
Jefferson Medical College
Kimmel Cancer Institute
BLSB, Room 1008
233 South 10th Street
Philadelphia, PA 19107Michelle LeBeau
University of Chicago
5841 South Maryland Avenue
Mailstop Code 2115
Chicago, IL 60637Kathleen E. Richkind
Genzyme Genetics
Cancer Cytogenetic Laboratory
Santa Fe, NMFrom Science News, Vol. 154, No. 20, November 14, 1998, p. 317. Copyright Ó 1998 by Science Service.
copyright 1998 ScienceService
