Do HIV-infected blobs run amok in AIDS?
HIV infection causes some immune-system cells to fuse into huge blobs that may cause damage within the body.
References:
Daniels, K.J. . . . D.R. Soll. 1998. HIV-induced T cell syncytia are motile, invasive, destructive, and seductive. Meeting of the American Society for Cell Biology. December. San Francisco.
Further Readings:
Frankel, S.S., et al. 1996. Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 272(April 5):115.
Soll, D.R. 1997. Researchers in cell motility and the cytoskeleton can play major roles in understanding AIDS. Cell Motility and the Cytoskeleton 37:91.
Sylwester, A. . . . D.R. Soll. 1997. HIV-induced T cell syncytia are self-perpetuating and the primary cause of T cell death in culture. Journal of Immunology 158:3996.
Sources:
Sarah S. Frankel
Armed Forces Institute of Pathology
Department of Infectious and Parasitic Disease Pathology
AIDS Division
Washington, DC 20306-6000David R. Soll
University of Iowa
Department of Biological Sciences
Iowa City, IA 52242
From Science News, Vol. 154, No. 25 & 26, December 19 & 26, 1998, p. 391. Copyright Ó 1998 by Science Service.
copyright 1998
ScienceService