Science News Online (12/19/98): References for Tumors often have phony protein receptor

< Back to Contents

Tumors often have phony protein receptor

Tumor tissue often has a membrane molecule that prevents the cells from responding to a signal that thwarts initiating programmed cell death, and thus the cancerous cell survives and replicates.

References:

Pitti, R.M. . . . and A. Ashkenazi. 1998. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 396(Dec. 17):699.

Further Readings:

Brunner, T. . . . D.R. Green. 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373(Feb. 2):441.

Griffith, T.S. . . . D.R. Green, et al. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270(Nov. 17):1189.

Nagata, S., and P. Golstein. 1995. The Fas death factor. Science 267(March 10):1449.

Seachrist, L. 1995. Slipping past the immune centurions. Science News 148(Oct. 21):263

Travis, J. 1997. HIV may spare cells—for a short time. Science News 151(June 14):371.

Williams, N. 1996. Tumor cells fight back to beat immune system. Science 274(Nov. 22):1302.

Sources:

Azi Ashkenazi
Genentech
1 DNA Way
South San Francisco, CA 94080

Douglas R. Green
La Jolla Institute for Allergy and Immunology
10355 Science Center Drive
San Diego, CA 92121

Alan N. Houghton
Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York, NY 10021

Noel R. Rose
Johns Hopkins University
Ross Research Building
720 Rutland Avenue, Room 648
Baltimore, MD 21205

From Science News, Vol. 154, No. 25 & 26, December 19 & 26, 1998, p. 391. Copyright Ó 1998 by Science Service.

Back to Table of Contents - 12/19/98