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Gene therapy for arthritis works in rats

 Transplanting DNA that encodes anti-inflammatory proteins combats arthritis in laboratory rats.

 

References:

Song, X. . . . S.M. Wahl. 1998. Plasmid DNA encoding transforming growth factor-b 1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. Journal of Clinical Investigation 101(June 15):2615.

 

Further Readings:

Hines, K.L., M. Christ, and S.M. Wahl. 1993. Cytokine regulation of the immune response: An in vivo model. Immunomethods 3:13.

Wahl, S.M. 1992. Transforming growth factor beta in inflammation. A cause and a cure. Journal of Clinical Immunology 12:1.

Additional information about arthritis can be found at the Arthritis Foundation Website at http://www.arthritis.org/research/arthritis_research.shtml.

Sources:

William P. Arend
University of Colorado
Division of Rheumatology
HSC B115
4200 East 9th Avenue
Denver, CO 80262

Sharon M. Wahl
National Institutes of Health
National Institute of Dental Research
Building 30, Room 332
Bethesda, MD 20892-4352

 

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