Tamoxifen may not prevent breast cancer
Contradicting a U.S. trial, studies in England and Italy showed no significant preventative effect of the drug tamoxifen in women at high risk of breast cancer.
From Science News, Vol. 154, No. 3, July 18, 1998, p. 37.
Copyright Ó 1998 by Science Service.
Powles, T., et al. 1998. Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial. Lancet 352(July 11):98.
Pritchard, K. 1998. Is tamoxifen effective in prevention of breast cancer? Lancet 352(July 11):80.
Veronesi, U., et al. 1998. Prevention of breast cancer with tamoxifen: Preliminary findings from the Italian randomised trial among hysterectomised women. Lancet 352(July 11):93.
Fuleihan, G.E. 1997. Tissue-specific estrogen the promise for the future. New England Journal of Medicine 337(Dec. 3):1686.
Kramer, B., and R. Klausner. 1997. Grappling with cancer defeatism versus the reality of progress. New England Journal of Medicine 337(Sept. 25):931.
Pritchard, K. 1997. Breast cancer: The real challenge. Lancet 349(March 1):psI24.
Raloff, J. 1998. Drug prevents some cancer, poses risks. Science News 153(April 11):228.
______. 1994. Tamoxifen turmoil. Science News 146(Oct. 22):268.
Seachrist, L. 1995. Tamoxifen use limited. Science News 148(Dec. 9):391.
Additional information about the Breast Cancer Prevention Trial can be found at the National Cancer Institute's Web site at: http://126.96.36.199/NCI_CANCER_TRIALS/zones/TrialInfo/.
Allegheny University of the Health Sciences
Allegheny General Hospital
320 East North Avenue
Pittsburgh, PA 15212
National Institutes of Health
National Cancer Institute
Division of Cancer Prevention
Building 31, Room 10A-49
Bethesda, MD 20892-2580
National Womens Health Network
514 10th Street, N.W., #400
Washington, DC 20004-1410
Kathleen I Pritchard
University of Toronto
Department of Medicine
Clinical Trials and Epidemiology
Toronto-Sunnybrook Regional Cancer Centre
2075 Bayview Avenue
Toronto, Ontario M4N 3M5
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