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Possible Alzheimer’s gene stirs conflict

Researchers disagree on whether a specific gene on chromosome 12 influences a person's chance of getting Alzheimer’s disease late in life.

 

References:

1998. APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease. Nature Genetics 19(August):321.

Alzheimer Association. Sixth International Conference on Alzheimer's Disease and Related Disorders. July. Amsterdam, Netherlands.

Blacker, D. . . . R.E. Tanzi. 1998. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nature Genetics 19(August):357.

 

Further Readings:

Price, D.L., S.S. Sisodia, and D.R. Borchelt. 1998. Alzheimer disease — when and why? Nature Genetics 19(August):314.

Sources:

Margaret A. Pericak-Vance
Duke University Medical Center
Department of Medicine
P.O. Box 3445
Durham, NC 27710

Peter H. St. George-Hsylop
University of Toronto
Tanz Neuroscience Building
6 Queen's Park Crescent West
Toronto, Ontario M5S 1A8
Canada

Rudolph E. Tanzi
Massachusetts General Hospital
Department of Neurology
Genetics and Aging Unit
Boston, MA 02114
E-mail: tanzi@helix.mgh.harvard.edu

 

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