View of HIV infection crystallizes
Atomic-scale pictures of an HIV protein reveal how the virus infects cells and eludes the immune system.
References:
Kwong, P.D. . . . J. Sodroski, and W.A. Hendrickson. 1998. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393(June 18):648.
Moore, J.P., and J. Binley. Envelopes letters boxed into shape. Nature 393(June 18):630.
Rizzuto, C.D. . . .W.A. Hendrickson, and J. Sodroski. 1998. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280(June 19):1949.
Further Readings:
Seppa, N. 1998. AIDS vaccine trial gets go-ahead. Science News 154(July 11):31.
Sources:
James Binley
Rockefeller University
Aaron Diamond AIDS Research Center
New York, NY 10021Wayne A. Hendrickson
Columbia University
Department of Biochemistry and Molecular Biophysics
Howard Hughes Medical Institute
New York, NY 10032
John P. Moore
Rockefeller University
Aaron Diamond AIDS Research Center
New York, NY 10021Joseph Sodroski
Department of Cancer Immunology and AIDS
Dana-Farber Cancer Institute
Boston, MA 02115
E-mail: joseph_sodroski@dfci.harvard.edu
7/25/98
copyright 1998 ScienceService