Amyloid Can Trigger
Brain Damage
Beta-amyloid, which is found in plaques in the brains of Alzheimer's disease patients, is more damaging to brain cells in old monkeys than in young ones.
References:
Geula, C. . . .B.A. Yankner. 1998. Aging renders the brain vulnerable to amyloid b -protein neurotoxicity. Nature Medicine 4(July):827.
Further Readings:
1998. Amyloid and Alzheimer disease. Nature Medicine 4(July):745.
Kisilevsky, R. 1998. Amyloid b threads in the fabric of Alzheimer's disease. Nature Medicine 4(July):772.
Lambert,M.P., et al. 1998. Diffusible, nonfibrillar ligands derived from Ab 1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences 95(May):6448.
Pennisi, E. 1994. A molecular whodunit. Science News 145(Jan. 1):8.
Pitschke, M., et al. 1998. Detection of single amyloid b protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectrascopy. Nature Medicine 4:832.
Seppa, N. 1998. Unveiling the tau of neurodegeneration. Science News 153(June 20):389.
Soto, C., et al. 1998. b -sheet breaker peptides inhibit fibrillogenesis in a rat model of amyloidosis: Potential Alzheimer's therapy. Nature Medicine 4:822.
Travis, J. 1997. New lesion found in Alzheimer brains. Science News 152(July 5):4.
Sources:
Ted M. Dawson
Johns Hopkins Medical Institutions
600 N. Wolfe Street
Carnegie Building
Room 214
Baltimore, MD 21287Bruce Yankner
Children's Hospital
Enders 260
300 Longwood Avenue
Boston, MA 02115
E-mail: Yankner@A1.tch.harvard.edu
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