References & Sources  -  September 12, 1998

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Tamoxifen clears hurdle to new use

An expert panel advised U.S. regulators to approve a powerful but toxic drug to cut a woman’s short-term risk of breast cancer, but European scientists argued the move was premature.

 

References:

Lasset, C. . . . H. Mignotte, et al. 1998. Prognosis of tamoxifen-associated endometrial cancer. Journal of Clinical Oncology 16(July):2573.

 

Further Readings:

1998. Cancer prevention, cancer risk. Washington Post (Sept. 8).

Brainard, J. 1998. Tamoxifen may not prevent breast cancer. Science News 154(July 18):37.

Mignotte, H., et al. 1998. Iatrogenic risks of endometrial carcinoma after treatment for breast cancer in a large French case-control study. International Journal of Cancer 76(May):325.

Powles, T.J., et al. 1998. The effects of norethisterone on endometrial abnormalities identified by transvaginal ultrasound screening of healthy post-menopausal women on tamoxifen or placebo. British Journal of Cancer 78(February):272.

Powles, T.J., et al. 1996. Effect of tamoxifen on bone mineral density measured by dual-energy X-ray absorptiometry in healthy premenopausal and postmenopausal women. Journal of Clinical Oncology 14(January):78.

Raloff, J. 1998. Drug prevents some cancer, poses risks. Science News 153(April 11):228.

______. 1997. Tamoxifen’s other anticancer hat. Science News 151(April 5):212.

______. 1996. U.N. body rules tamoxifen a carcinogen. Science News 149(March 2):132.

______. 1994. Tamoxifen turmoil. Science News 146(Oct. 22):268.

______. 1994. FDA, others offer new tamoxifen warnings. Science News 145(April 16):247.

______. 1994. Studies spark new tamoxifen controversy. Science News 145(Feb. 26):133.

______. 1993. [Tamoxifen slashes serum cholesterol] . . . but shows link to ‘bad’ uterine cancers. Science News 144(Sept. 25):207.

Seachrist, L. 1996. Tamoxifen therapy should last 5 years. Science News 150(Nov. 23):335.

______. 1995. Tamoxifen use limited. Science News 148(Dec. 9):391.

Travis, J. 1997. Guardians of the Genome? Science News 151(June 21):386.

 

Sources:

Kathy S. Albain
Loyola University Medical Center
Division of Hematology/Oncology
Cancer Center, Room 109
2160 South First Avenue
Maywood, IL 60153

Hervé Mignotte
Centre Léon Bérard
28, rue Laënnec
69373 Lyon cedex 08
France

Trevor J. Powles
Royal Marsden NHS Trust
Downs Road
Sutton, Surrey SM2 5PT
United Kingdom

From Science News, Vol. 154, No. 11, September 12, 1998, p. 166.
Copyright © 1998 by Science Service.

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