References & Sources  -  September 12, 1998

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A protein is pivotal in prostate cancer

Destruction of a cancer-suppressing protein occurs most often in the most aggressive prostate cancers.

 

References:

Cordon-Cardo, C., et. al. 1998. Distinct altered patterns of p27^KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. Journal of the National Cancer Institute 90(Sept. 2):1284.

 

Further Readings:

Boyle, P. 1997. Global burden of cancer. Lancet 349(May 17):SII23.

Frydenberg, M., P.D. Stricker, and K.W. Kaye. 1997. Prostate cancer diagnosis and management. Lancet 349(June 7):1681.

Loda, M., et al. 1997. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nature Medicine 3(February):231.

Lu-Yao, G.L., and S.-L. Yao. 1997. Population-based study of long-term survival in patients with clinically localised prostate cancer. Lancet 349(March 29):906.

Taplin, M.-E., et al. 1995. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. New England Journal of Mecicine 332(May 25):1393.

Sources:

Carlos Cordon-Cardo
Memorial Sloan-Kettering Cancer Center
Department of Pathology
1275 York Avenue
New York, NY 10021

Massimo Loda
Dana-Farber Cancer Institute
Smith 858A
44 Binney Street
Boston, MA 02115

Michele Pagano
New York University
Kaplan Comprehensive Cancer Center
MSB 548
550 First Avenue
New York, NY 10016

From Science News, Vol. 154, No. 11, September 12, 1998, p. 167. Copyright © 1998 by Science Service.

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