A Controversial Shot in the Arm 
Possible AIDS vaccine taps an unlikely protein called Tat
Debate over the
roles of an HIV protein previously recognized as helping the virus turn
on its genes hasn’t stopped scientists from using it in experimental
vaccinations against AIDS.
References:
Cafaro, A. . . .
and B. Ensoli. 1999. Control of SHIV-89.6P-infection of cynomolgus
monkeys by HIV-1 Tat protein vaccine. Nature Medicine
5(June):643.
Cohen, S.S. . .
. and D.I. Cohen. 1999. Pronounced acute immunosuppression in vivo
mediated by HIV Tat challenge. Proceedings of the National Academy
of Sciences 96(Sept. 14):10842.
Gallo, R.C.
1999. Tat as one key to HIV-induced immune pathogenesis and Pat toxoid
as an important component of a vaccine. Proceedings of the National
Academy of Sciences 96(July 20):8324.
Osterhaus,
A.D.M.E., et al. 1999. Vaccination with Rev and Tat against
AIDS. Vaccine 17(June):2713.
Zagury, D. . . .
and R.C. Gallo. 1998. Interferon a and Tat involvement in the
immunosuppression of uninfected T cells and C-C chemokine decline in
AIDS. Proceedings of the National Academy of Sciences 95(March
31):3851.
Further Readings:
Albini, A., et
al. 1998. HIV-1 Tat protein mimicry of chemokines. Immunology
95(Oct. 27):13153.
Goldstein, G.
1996. HIV-1 Tat protein as a potential AIDS vaccine. Nature Medicine
1(September):960.
Gringeri, A., et
al. 1999. Tat toxoid as a component of a preventive vaccine in
seronegative subjects. Journal of Acquired Immune Deficiency
Syndromes and Human Retrovirology 20(April):371.
Gringeri, A., et
al. 1998. Safety and immunogenicity of HIV-1 Tat toxoid in
immunocompromised HIV-1 infected patients. Journal of Human Virology
1(May):293.
Huang, L., et
al. 1998. Tat protein induces human immunodeficiency virus type 1
(HIV-1) coreceptors and promotes infection with both macrophage-tropic
and T-lymphotropic HIV-1 strains. Journal of Virology
72(November):8952.
Ott, M. . . . and
E. Verdin. 1997. Immune hyperactivation of HIV-1–infected T cells
mediated by Tat and the CD28 pathway. Science 275(March 7):1481.
Travis, J. 1997.
HIV protein prepares virus’ next victims. Science News 152(July
26):53.
van Baalen, C.A., et
al. 1997. Human immunodeficiency virus type 1 Rev- and Tat-specific
cytotoxic T lymphocyte frequencies inversely correlate with rapid
progression to AIDS. Journal of General Virology 78(August):1913.
Sources:
David I. Cohen
Queens College
Bernard and Gloria Salick Center for Molecular and Cellular
Biology
Flushing, NY 11367
Barbara Ensoli
Istituto Superiore di Sanità
Laboratory of Virology
00161 Rome
Italy
Robert C. Gallo
University of Maryland, Baltimore
Institute of Human Virology
725 West Lombard Street, 3rd Floor
Baltimore, MD 21201-1192
Beatrice Hahn
University of Alabama at Birmingham
Department of Microbiology
701 South 19th Street
LHRB-613
Birmingham, AL 35294
John P. Moore
Rockefeller University
Aaron Diamond AIDS Research Center
1230 York Avenue
New York, NY 10021
Gary Nabel
National Institutes of Health
National Vaccine Research Center
Bethesda, MD 20892
Ab Osterhaus
Erasmus Medical Centre Rotterdam
Dr Molewaterplein 50
3015 GE Rotterdam
Netherlands
C. David Pauza
University of Wisconsin-Madison
School of Medicine
Department of Pathology and Laboratory Medicine
515 SMI Medical Science Center
1300 University Avenue
Madison, WI 53792
Andrew P. Rice
Baylor College of Medicine
Department of Molecular Virology
Houston, TX 77030
Eric M. Verdin
University of California, San Francisco
Gladstone Institute of Virology and Immunology
P.O. Box 419100
San Francisco, CA 94141-9100
Daniel Zagury
Université Pierre et Marie Curie
4, place Jussieu
75005 Paris
France
From Science
News, Vol. 156, No. 19, November 6, 1999, p. 300. Copyright © 1999,
Science Service. |