Enzyme offers promise of Alzheimer’s drugs - References and Sources, Science News Online (11/6/99)

Enzyme offers promise of Alzheimer’s drugs

Scientists have finally identified an enzyme that may help cause Alzheimer’s disease.

References:

Hussain, I., et al. In press. Identification of a novel aspartic protease (Asp 2) as b -secretase. Molecular and Cellular Neuroscience.

Saunders, A.J. 1999. Alpha-2-macroglobulin mediated Ab internalization and degradation. Meeting of the Society for Neuroscience. October. Miami Beach.

Sinha, S., et al. 1999. Characterization of membrane-bound and solubilized g -secretase-like activity. Meeting of the Society for Neuroscience. October. Miami Beach.

Vassar, R. . . . and M. Citron. 1999. b -secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286(Oct. 22):735.

Further Readings:

Travis, J. 1997. A surprising role for Alzheimer proteins? Science News 152(Sept. 20):182.

Sources:

Martin Citron
Amgen
One Amgen Center Drive
Mailstop Code 29-2-B
Thousand Oaks, CA 91320

Todd E. Golde
Mayo Clinic
4500 San Pablo Road
Jacksonville, FL 32224

Lennart Mucke
University of California, San Francisco
Gladstone Institute of Neurological Disease
P.O. Box 419100
San Francisco, CA 94141-9100

Michael J. Mullan
University of South Florida
Department of Psychiatry
3515 East Fletcher Avenue
Tampa, FL 33613

Aleister J. Saunders
Harvard Medical School
Massachusetts General Hospital
Department of Psychiatry
Genetics and Aging Unit
Building 149, 13th Street
Boston, MA 02129

Sukanto Sinha
Elan Pharmaceuticals
800 Gateway Boulevard
South San Francisco, CA 94080