Self cells ease Parkinson's
in monkeys
Cells from the carotid-body glands
in the neck, transplanted into the brains of monkeys with Parkinson's
disease, facilitate the production of dopamine and lessen muscle rigidity
and other symptoms of the disease.
References:
Luquin, M.R. . . . and J. López-Barneo. 1999. Recovery of chronic
Parkinsonian monkeys by autotransplants of carotid body cell aggregates
into putamen. Neuron 22(April).
Further Readings:
Barinaga, M. 1998. Unusual cells may help treat Parkinson's disease.
Science 279(Feb. 27):1301.
Fackelmann, K. 1995. Fetal cells thrive in a Parkinsonian brain.
Science News 147(April 29):262.
Fishman, M.C., W.L. Green, and D. Platika. 1985. Oxygen chemoreception
by carotid body cells in culture. Proceedings of the National Academy
of Sciences 82:1448.
Freed, C.R., et al. 1992. Survival of implanted fetal dopamine
cells and neurologic improvement 12 and 46 months after transplantation
for Parkinson's disease. New England Journal of Medicine 327:1549.
Kordower, J.H. . . . P.R. Sanberg, et al. 1995. Neuropathological
evidence of graft survival and striatal reinnervation after the transplantation
of fetal mesencephalic tissue in a patient with Parkinson's disease.
New England Journal of Medicine 332(April 27):118.
Rosenthal, A. 1998. Auto transplants for Parkinson's disease? Neuron
20:169.
Sources:
Greg A. Gerhardt
University of Colorado Health Sciences Center
Department of Psychiatry
4200 East Ninth Avenue
Box C268-71
Denver, CO 80262
José López-Barneo
Universidad de Sevilla
Departamento de Fisiologia Médica y Biofísica
Facultad de Medicina
E-41009 Sevilla
Spain
Paul R. Sanberg
University of South Florida
Department of Neurosurgery
College of Medicine
12910 Bruce B. Downs Boulevard
Tampa, FL 33612
From Science
News, Vol. 155, No. 17, April 24,
1999, p. 260. Copyright © 1999, Science Service.
