Therapy pits useful
gene against tumor
A cancer-suppressor gene called
p53, packaged in a disabled virus, temporarily thwarted tumor
growth in more than half of lung patients who received it.
References:
Swisher, S.G., J.A. Roth, et al. 1999. Adenovirus-mediated
p53 gene transfer in advanced non-small-cell lung cancer. Journal
of the National Cancer Institute 91(May 5):763.
Further Readings:
Larkin, M. 1996. Promising results reported for lung cancer gene
therapy. Lancet 348(Sept. 7):671.
Roth, J.A., et al. 1996. Retrovirus-mediated wild-type p53
gene transfer to tumors of patients with lung cancer. Nature Medicine
2:985.
Skuse, G.R. 1995. Tumour suppressor genes in disease and therapy.
Lancet 345(April 8):902.
Travis, J. 1996. Putting a tumor suppressor back to work. Science
News 150(Aug. 31):134.
Sources:
Jack A. Roth
University of Texas
M.D. Anderson Cancer Center
1515 Holcombe Boulevard
Box 109
Houston, TX 77030
From Science
News, Vol. 155, No. 20, May 15, 1999, p. 310.
Copyright © 1999, Science Service.
