Thwarting killer enzymes
of the brain
Enzymes called caspases may play
a crucial role in the death of brain cells observed in Huntington's
disease.
References:
Ona, V.O. . . . and R.M. Friedlander. 1999. Inhibition of caspase-1
slows disease progression in a mouse model of Huntington's disease.
Nature 399(May 20):263.
Sánchez, I. . . . and J. Yuan. 1999. Caspase-8 is required for cell
death induced by expanded polyglutamine repeats. Neuron 22(March):623.
Sources:
Robert M. Friedlander
Harvard Medical School
Brigham and Women's Hospital
Neurosurgical Service
Department of Surgery
Boston, MA 02115
Christopher A. Ross
Johns Hopkins University
School of Medicine
Laboratory of Molecular Neurobiology
Department of Psychiatry
Department of Neuroscience
Baltimore, MD 21205
Junying Yuan
Harvard Medical School
Department of Cell Biology
Boston, MA 02115
From Science
News, Vol. 155, No. 22, May 29, 1999, p. 351.
Copyright © 1999, Science Service.
