| Enzyme
encourages cancer’s deadly spread
Two research teams
have identified the gene encoding an enzyme that helps cancer cells
spread.
References:
Hulett, M.D. . .
. C.R. Parish. 1999. Cloning of mammalian heparanase, an important
enzyme in tumor invasion and metastasis. Nature Medicine 5(July):803.
Vlodavsky, I, et
al. 1999. Mammalian heparanase: Gene cloning, expression and
function in tumor progression and metastasis. Nature Medicine
5(July):793.
Further Readings:
Eccles, S.A. 1999.
Heparanase: Breaking down barriers in tumors. Nature Medicine
5(July):735.
Parish, C.R., et
al. 1999. Identification of sulfated oligosaccharide-based
inhibitors of tumor growth and metastasis using novel in vitro
assays for angiogenesis and heparanase activity. Cancer Research
59(July 15):3433.
Sources:
Christopher R.
Parish
John Curtin School of Medical Research
Australian National University
Division of Immunology and Cell Biology
Canberra ACT 0200
Australia
Israel Vlodavsky
Hadassah-Hebrew University Hospital
Department of Oncology
Jerusalem 91120
Israel
From Science
News, Vol. 156, No. 4, July 24, 1999, p. 53. Copyright © 1999,
Science Service. |