Malaria disrupts the
immune system
The single-celled organism that
causes malaria also disrupts the immune system, a laboratory study shows.
References:
Urban, B.C. ... and D.J. Roberts. 1999. Plasmodium falciparum-infected
erythrocytes modulate the maturation of dendritic cells. Nature
400(July 1):73.
Further Readings:
Gardner, J.P., et al. 1996. Variant antigens and endothelial
receptor adhesion in Plasmodium falciparum. Proceedings
of the National Academy of Sciences 93:3503.
Gilbert, S.C., et al. 1998. Association of malaria parasite
population structure, HLA, and immunological antagonism. Science
279:1173.
Nowak, R. 1995. How the parasite disguises itself. Science
269(Aug. 11):755.
Nussenzweig, R.S., and F. Zavala. 1997. A malaria vaccine based on
a sporozoite antigen. New England Journal of Medicine 336(Jan.
9):128.
Williams, N. 1998. Malaria strains appear to gang up against immune
defenses. Science 279(Feb. 20):1136.
Wirth, D.F., and J. Cattani. 1997. Winning the war against malaria.
MIT's Technology Review 100(Aug./Sept.):52.
Sources:
W. Ripley Ballou
Walter Reed Army Institute of Research
Department of Immunology
Building 40, Room 1033
Washington, DC 20307-5100
David J. Roberts
John Radcliffe Hospital
Institute of Molecular Medicine
Headington, Oxford 0X3 9DU
England
Britta C. Urban
John Radcliffe Hospital
Institute of Molecular Medicine
Headington, Oxford 0X3 9DU
England
From Science
News, Vol. 156, No. 1, July 3, 1999, p. 4.
Copyright © 1999, Science Service.
