Diabetes drug stirs cancer confusion
Though troglitazone may thwart human colon cancer in some cases, the widely prescribed drug may also trigger the cancer in genetically susceptible people.
Lefebvre, A.-M. . . . J. Awerx. 1998. Activation of the peroxisome proliferator-activated receptor g promotes the development of colon tumors in C57BL/6J-APCMin/+mice. Nature Medicine 4(September):1053.
Saez, E. . . . R.M. Evans. 1998. Activators of the nuclear receptor PPARg enhance colon polyp formation. Nature Medicine 4(September):1058.
Sarraf, P. . . . B.M. Spiegelman. 1998. Differentiation and reversal of malignant changes in colon cancer through PPARg . Nature Medicine 4(September):1046.
Seed, B. 1998. PPARg and colorectal carcinoma: Conflicts in a nuclear family. Nature Medicine 4(September):1004.
Ronald M. Evans
Howard Hughes Medical Institute
Salk Institute for Biological Studies
La Jolla, CA 92037
Bruce M. Spiegelman
Dana-Farber Cancer Institute
Department of Cell Biology
Harvard Medical School
Boston, MA 02115
From Science News, Vol. 154, No. 16, October 17, 1998,
Copyright Ó 1998 by Science Service.
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copyright 1998 ScienceService