Science News Online (7/25/98): References for The Overworked Heart -- Research suggests molecular mechanisms for heart failure

References & Sources - July 25, 1998

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Research suggests molecular mechanisms for heart failure

Identifying proteins and enzymes implicated in heart damage may lead to ways of preventing or even reversing congestive heart disease.

References:

Bozkurt, B. . . . D.L. Mann. 1998. Pathophysiologically relevant concentrations of tumor necrosis factor-a promote progressive left ventricular dysfunction and remodeling in rats. Circulation 97(April 14):1382.

Bristow, M.R. 1998. Tumor necrosis factor-a and cardiomyopathy. Circulation 97(April 14):1340.

Bryant, D. . . . B. Giroir. 1998. Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-a . Circulation 97(April 14):1375.

Mann, D.L. 1997. The American Heart Association's 70th Scientific Sessions. Orlando, Fla.

Rockman, H.A., et al. 1998. Expression of a b -adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences 95(June 9):7000.

Further information may be found at this Web site: http://www.swmed.edu/home_pages/cardiology/labs/jarlab.html.

Sources:

Michael R. Bristow
University of Colorado Health Sciences Center
Division of Cardiology
4200 East 9th Avenue
Denver, CO 80262

Debora Bryant
University of Texas
Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, TX 75235

Brett Giroir
University of Texas
Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, TX 75235

Douglas L. Mann
Virginia Medical Center
Cardiology Research
2002 Holcombe Boulevard
Houston, TX 77030

Howard A. Rockman
University of North Carolina, Chapel Hill
Department of Medicine
CB #7075
Chapel Hill, NC 27599

James B. Young
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195

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