References & Sources  -  August 1, 1998

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Asthma drug’s effect fades over time

After 2 weeks of regular use, morning doses of an asthma preventive, salmeterol, fail to ward off attacks late in the day.

References:

Nelson, J.A. . . . E.R. McFadden, Jr. 1998. Effect of long-term salmeterol treatment on exercise-induced asthma. New England Journal of Medicine 339(July 16):141.

Further Readings:

Cheung, D., et al. 1992. Long-term effects of a long-acting b ₂-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma. New England Journal of Medicine 327:1198.

Fitzpatrick, M.F., et al. 1990. Salmeterol in nocturnal asthma: A double blind, placebo controlled trial of a long acting inhaled b ₂-agonist. BMJ 301:1365.

Sources:

E.R. McFadden, Jr.
University Hospitals of Cleveland
Division of Pulmonary and Critical Care Medicine
11100 Euclid Avenue
Cleveland, OH 44106-5067

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