Asthma drugs effect fades over time
After 2 weeks of regular use, morning doses of an asthma preventive, salmeterol, fail to ward off attacks late in the day.
Nelson, J.A. . . . E.R. McFadden, Jr. 1998. Effect of long-term salmeterol treatment on exercise-induced asthma. New England Journal of Medicine 339(July 16):141.
Cheung, D., et al. 1992. Long-term effects of a long-acting b 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma. New England Journal of Medicine 327:1198.
Fitzpatrick, M.F., et al. 1990. Salmeterol in nocturnal asthma: A double blind, placebo controlled trial of a long acting inhaled b 2-agonist. BMJ 301:1365.
E.R. McFadden, Jr.
University Hospitals of Cleveland
Division of Pulmonary and Critical Care Medicine
11100 Euclid Avenue
Cleveland, OH 44106-5067
Back to Table of Contents -8/1/98
copyright 1998 ScienceService