Science News Online (8/22/98): References for Stroke Rescue

References & Sources - August 22, 1998

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Can cells injected into the brain reverse paralysis?

Using a novel, experimental therapy, surgeons have injected laboratory-grown, immature nerve cells into a patient's stroke-damaged regions.

References:

Borlongan, C.V., et al. 1998. Viability and survival of hNT neurons determine degree of functional recovery in grafted ischemia rats. NeuroReport 9(Aug. 24).

Borlongan, C.V. . . . V.M.-Y. Lee, and P.R. Sanberg. 1998. Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Experimental Neurology 149:310.

Further Readings:

Fackelmann, K.A. 1995. Fetal cells thrive in a Parkinsonian brain. Science News 147(April 29):262.

Travis, J. 1996. Fetal cells tried for Huntington’s. Science News 150(Dec. 21&28):399.

Trojanowski, J.Q., et al. 1993. Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain. Experimental Neurology 122(February):283.

Sources:

Cesario V. Borlongan
National Institutes of Health
National Institute on Drug Abuse
5500 Nathan Shock Drive
Baltimore, MD 21224

Don M. Gash
University of Kentucky
Department of Anatomy and Neurobiology
Lexington, KY 40506

Barry J. Hoffer
National Institutes of Health
National Institute on Drug Abuse
5500 Nathan Shock Drive
Baltimore, MD 21224

Douglas Kondziolka
University of Pittsburgh
Department of Neurological Surgery
3811 O’Hara Street
Pittsburgh, PA 15213-2593

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