Is Your Stomach Bugging You? - References and Sources, Science News Online (10/9/99)

Is Your Stomach Bugging You?

The rise and fall of the bacterium H. pylori

Now that doctors are aggressively treating people infected with H. pylori—a bacterium that causes ulcers and has been linked to stomach cancer—a maverick researcher warns that too-quick eradication of the ulcer bug may also have risks.

References:

Blaser, M.J. 1999. In a world of black and white, Helicobacter pylori is gray. Annals of Internal Medicine 130(April 20):695.

______. 1999. Hypothesis: The changing relationships of Helicobacter pylori and humans: Implications for health and disease. Journal of Infectious Diseases 179(June):1523.

Covacci, A. . . . and R. Rappuoli. 1999. Helicobacter pylori, virulence, and genetic geography. Science 284(May 21):1328.

Dore, M.P. . . . and D.Y. Graham. 1999. Helicobacter pylori in sheep milk. Lancet 354(July 10):132.

Graham, D.Y., et al. 1999. Scope and consequences of peptic ulcer disease. Scope and Consequences 105(March):100.

Peek Jr., R.M. . . . and M.J. Blaser. 1999. Role of Helicobacter pylori cagA⁺ strains and specific host immune responses on the development of premalignant and malignant lesions in the gastric cardia. International Journal of Cancer 82:520.

Pütsep, K . . . H.G. Boman, et al. 1999. Antibacterial peptide from H. pylori. Nature 398(April 22):671.

Further Readings:

Chow, W.-H., M.J. Blaser, et al. 1998. An inverse relation between cagA⁺ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Research 58(Feb. 15):588.

Fendrick, A.M., et al. 1999. Clinical and economic effects of population-based Helicobacter pylori screening to prevent gastric cancer. Archives of Internal Medicine 159(Jan. 25):142.

Sources:

Martin J. Blaser
Vanderbilt University School of Medicine
Department of Medicine
Division of Infectious Diseases
2200 West End Avenue
Nashville, TN 37235

Hans G. Boman
Karolinska Institute
Microbiology and Tumor Biology Center
SE-171 77 Stockholm
Sweden

A. Mark Fendrick
University of Michigan, Ann Arbor
Department of Internal Medicine and Health Management and Policy
3116 Taubman, Box 0376
Ann Arbor, MI 48109-0376

David Y. Graham
Baylor College of Medicine
Department of Medicine Gastroenterology
Veterans Affairs Medical Center
VAMC 3A320
Houston, TX 77030

Adrian Lee
University of New South Wales
School of Microbiology and Immunology
Sydney 2052
Australia

Rino Rappuoli
IRIS
Chiron SpA
Via Fiorentina 1
53100 Siena
Italy