Two very different forms of surgery show promise in treating Parkinson’s disease.

De Bie, R.M.A., et al. 1999. Unilateral pallidotomy in Parkinson’s disease: A randomised, single-blind, multicentre trial. Lancet 354(Nov. 13):1665.

Freed, C.R., et al. 1999. Double-blind placebo-controlled human fetal dopamine cell transplants in advanced Parkinson’s Disease. Meeting of the Society for Neuroscience. October. Miami Beach, Fla.

Paccini, P., et al. 1999. Dopamine release from nigral transplants visualized in vivo in a Parkinson’s patient. Nature Neuroscience 2(December):1137.

Quinn, N. 1999. Progress in functional neurosurgery for Parkinson’s disease. Lancet 354(Nov. 13):1658.

Barker, R.A., and S.B. Dunnett. 1999. Functional integration of neural grafts in Parkinson’s disease. Nature Neuroscience 2(December):1047.

Kordower, J.H., et al. 1995. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson’s disease. New England Journal of Medicine 332:1118.

Lozano, A.M., et al. 1995. Effect of GPi pallidotomy on motor function in Parkinson’s disease. Lancet 346:1383.

Rob M.A. de Bie
Department of Neurology
(H2-222)
Academic Medical Centre
P.O. Box 22700
1100 DE Amsterdam
The Netherlands

Curt R. Freed
University of Colorado
Health Sciences Center
4200 East 9^th Avenue
Denver, CO 80262

Paola Piccini
Imperial College School of Medicine
Hammersmith Hospital
MRC Cyclotron Unit
Du Cane Road
London W12 0NN
United Kingdom

Niall Quinn
Institute of Neurology
Department of Clinical Neurology
London WC1N 3BG
United Kingdom

From Science News, Vol. 156, No. 22, November 27, 1999, p. 342. Copyright © 1999, Science Service.