A new cell-killing strategy, often called molecular neurosurgery, may one day help people overcome pain that even morphine and other narcotics can’t control.

Benoliel, R. . . . and M.J. Iadarola. 1999. Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain. Pain 79(February):243.

Martin, W.J. et al. 1999. Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 80(March):57.

Nichols, M.L. . . . D.A. Lappi . . . and P.W. Mantyh. 1999. Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science 286(Nov. 19):1558.

Wiley, R.G. 1999. Inhibition of mustard oil-induced hyperalgesia in an operant escape task by substance P-saporin. Society for Neuroscience Meeting. October. Miami Beach, Fla.

Simpson, S. 1999. Pain, pain, go away. Science News 155(Feb. 13):108.

Michael J. Iadarola
National Institutes of Health
National Institute of Dental and Craniofacial Research
Pain and Neurosensory Mechanisms Branch
49 Convent Drive
Room 1A11, MSC 4410
Bethesda, MD 20892

Douglas A. Lappi
Advanced Targeting Systems
11175-A Flintkote Avenue
San Diego, CA 92121

Patrick W. Mantyh
University of Minnesota
Departments of Preventive Sciences, Psychiatry, and Neuroscience and Cancer Center
Minneapolis, MN 55455

William J. Martin
Merck & Co.
Merck Research Laboratories
P.O. Box 2000, RY8OY-135
Rahway, NJ 07065

Lorne M. Mendell
State University of New York at Stony Brook
Department of Neurobiology and Behavior
550 Life Sciences Building
Stony Brook, NY 11794-5230

David A. Thomas
National Institute on Drug Abuse
Division of Basic Research
5600 Fishers Lane, Room 10A-19
Rockville, MD 20857

Ronald G. Wiley
Vanderbilt University
Veterans Affairs Medical Center
Neurology and Pharmacology
Nashville, TN 37212-2637

From Science News, Vol. 156, No. 23, December 4, 1999, p. 362. Copyright © 1999, Science Service.