References & Sources - January 16, 1999

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Gene injections stem clotting disorder

Successful gene therapy treatment of hemophiliac dogs may lead to human trials by the end of the year.

References:

Herzog, R.W. . . . and K.A. High. 1999. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nature Medicine 5(January):56.

Linden, R.M., and S.L.C. Woo. 1999. AAVant-garde gene therapy. Nature Medicine 5(January):21.

Snyder, R.O. . . . and M.A. Kay. 1999. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nature Medicine 5(January):64.

Further Readings:

Fackelmann, K.A. 1993. Gene therapy ameliorates clotting disorder. Science News 144(Oct. 2):215.

Additional information about hemophilia B can be found at http://www.infonhf.org/front_page/.

Sources:

Katherine High
Children's Hospital of Philadelphia
Division of Hematology
310A Abramson Research Center
34th Street and Civic Center Boulevard
Philadelphia, PA 19104

Mark A. Kay
Stanford University School of Medicine
Department of Pediatrics and Genetics
300 Pasteur Drive, Room G-305A
Stanford, CA 94195

From Science News, Vol. 155, No. 3, January 16, 1999, p. 37. Copyright © 1999, Science Service.

Copyright 1999 Science Service