References & Sources - January 16, 1999
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Insulin-resistance gene defect identified
A study in rats found that a defect in the Cd36 gene leads to insulin resistance, reducing the hormone's efficiency in processing sugars.
Aitman, T.J., et al. 1999. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nature Genetics 21(January):76.
Aitman, T.J., et al. 1997. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nature Genetics 16:197.
Barnett, A.H. 1993. Microalbuminuria and insulin resistance in diabetes mellitus. Lancet 342(Oct. 9):880.
Clausen, J.O., et al. 1995. Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 346(Aug. 12):397.
Reaven, G.M. 1988. Role of insulin resistance in human disease. Diabetes 37:1595.
Reaven, G.M., H. Lithell, and L. Landsberg. 1996. Hypertension and associated metabolic abnormalities-the role of insulin resistance and the sympathoadrenal system. New England Journal of Medicine 334:374.
Wang, P.H., and M. Korc. 1995. Searching for the Holy Grail: The cause of diabetes. Lancet 346(Dec. 23&30):S4.
Additional information about diabetes is located at http://www.diabetes.org/ada/c20b.asp.
Timothy J. Aitman
Imperial College School of Medicine
Division of National Heart and Lung Institute
Graeme I. Bell
University of Chicago
Howard Hughes Medical Institute
5841 South Maryland Avenue
Mailstop Code 028
Chicago, IL 60637
Ping H. Wang
University of California, Irvine
Department of Medicine
Medical Science 1
Irvine, CA 92697
From Science News, Vol. 155, No. 3, January 16, 1999, p. 38. Copyright © 1999, Science Service.
Copyright 1999 Science Service