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Prospects Dim for Live AIDS Vaccine
A live AIDS vaccine missing pieces of three key genes causes the simian form of the disease in monkeys, casting doubt on the prospect of using such an attenuated vaccine against HIV in humans.
References:
Baba, T.W. . . . and, R.M. Ruprecht. 1999. Live attenuated, multiply deleted simian immunodeficiency viruses causes AIDS in infant and adult macaques. Nature Medicine 5(February):194.
Berkhout, B., et al. 1999. Genetic instability of live, attenuated human immunodeficiency virus type 1 vaccine strains. Journal of Virology 73(February):1138.
Further Readings:
1997. Weakened SIV vaccine still kills. Science 278(Oct. 3):24.
Baba, T.W., et al. 1995. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267:1820.
Daniel, M.D., et al. 1992. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258:1938.
Kleiner, K. 1997. Live and dangerous. New Scientist 156(Oct. 4):5.
Spence, R.A., et al. 1995. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 267(Feb. 17):988.
Sources:
Ruth I. Connor
Aaron Diamond AIDS Research Center
455 First Avenue, 7th Floor
New York, NY 10016
Margaret I. Johnston
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard
Bethesda, MD 20892
Ruth M. Ruprecht
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA 02115
David H. Schwartz
Johns Hopkins University
School of Public Health
Department of Molecular Biology and Immunology
615 North Broadway
Baltimore, MD 21205
From Science News, Vol. 155, No. 7, February 13, 1999, p. 100. Copyright © 1999, Science Service.
