Drug blockades blood vessels' energy
The anticancer drug angiostatin blocks the energy storage of cells in blood vessels that must grow to sustain tumors.
References:
Moser, T.L., et al. 1999. Angiostatin binds ATP synthase on the surface of human endothelial cells. Proceedings of the National Academy of Sciences 96(March 16):2811.
Further Readings:
Brownlee, S., and N. Shute. 1998. Killing cancer. U.S. News Online. Available at http://www.usnews.com/usnews/issue/980518/18canc.htm.
Fackelmann, K.A. 1998. Tumor-starving drugs show promise. Science News 153(May 2):286.
Sources:
Judah Folkman
Children's Hospital
Department of Surgery
Boston, MA 02115
Gordon G. Hammes
Duke University Medical Center
Department of Biochemistry
436A Nanaline H Duke
Box 3711
Durham, NC 27710
Tammy L. Moser
Duke University Medical Center
Department of Pathology
Box 3712
Durham, NC 27710
Salvatore Pizzo
Duke University Medical Center
Department of Pathology
Box 3712
Durham, NC 27710
From Science News, Vol. 155, No. 12, March 20, 1999, p. 183. Copyright © 1999, Science Service.
