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Marrow transplant fights bone disease
Children born with a hereditary bone disease called osteogenesis imperfecta show improvement when given bone marrow transplants from healthy siblings.
References:
Horwitz, E.M., et al. 1999. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nature Medicine 5(March):309.
Further Readings:
Fishman, R.H.B. 1998. New conditioning could make bone-marrow transplant more "user friendly." Lancet 351(Feb. 21):535.
Gerson S.L. 1999. Mesenchymal stem cells: No longer second class marrow citizens. Nature Medicine 5(March):262.
Marini, J.C., and N.L. Gerber. 1997. Osteogenesis imperfecta. Journal of the American Medical Association 277(March 5):746.
Prockop, D.J. 1997. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276(April 4):71.
Sources:
Stanton L. Gerson
Case Western Reserve University
Division of Hematology and Oncology
BRB-3, Ireland Cancer Center
10900 Euclid Avenue
Cleveland, OH 44106
Edwin M. Horwitz
St. Jude's Children's Research Hospital
Cell and Gene Therapy Program
332 North Lauderdale
Memphis, TN 38105
From Science News, Vol. 155, No. 10, March 6, 1999, p. 148. Copyright © 1999, Science Service.
