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Simulations nab protein-folding mistakes
Researchers have developed the first computational model that captures how one protein strand can interfere with the folding of another.
References:
Istrail, S., J. King, and R. Schwartz. In press. Lattice simulations of aggregation funnels for protein folding. Journal of Computational Biology. Available at http://www.cs.sandia.gov/~scistra/.
Further Readings:
Hayes, B. 1998. Prototeins. American Scientist 86(May-June):216.
Peterson, I. 1997. Computing nuclear crash and burn scenarios. Science News 152(July 5):5.
Richards, F.M. 1991. The protein folding problem. Scientific American (January):54.
Seppa, N. 1998. Amyloid can trigger brain damage. Science News 154(July 4):4.
Wu, C. 1998. Hot-blooded proteins. Science News 153(May 9):296.
Sources:
Ken Dill
University of California
Department of Pharmaceutical Chemistry
San Francisco, CA 94305
Sorin Istrail
Sandia National Laboratories
Mail Stop 1110, Department 9222
Albuquerque, NM 87185-1110
Web site: http://www.cs.sandia.gov/~scistra/
Jonathan A. King
Massachusetts Institute of Technology
Department of Biology
Cambridge, MA 02139
Web site: http://web.mit.edu/biology/www/Ar/king.html
From Science News, Vol. 155, No. 10, March 6, 1999, p. 150. Copyright © 1999, Science Service.
