Stopping leaks may boost cancer drugs

A small protein fragment within two promising cancer drugs underlies their dangerous side effect, leaky blood vessels.

References:

Baluna, R. . . . and E.S. Vitetta. 1999. Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. Proceedings of the National Academy of Sciences 96(March 30):3957.

Sources:

Daniel A. Vallera
University of Minnesota Cancer Center
Department of Therapeutic Radiology
Box 806 Mayo
420 Delaware Street, SE
Minneapolis, MN 55455

Ellen S. Vitetta
University of Texas Southwestern Medical Center
Cancer Immunobiology Center
5323 Harry Hines Boulevard
Dallas, TX 75235-8675

From Science News, Vol. 155, No. 15, April 10, 1999, p. 231. Copyright © 1999, Science Service.

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