Drugs tackle cancer in unexpected way

Drugs known as farnesyltransferase inhibitors appear to check tumor growth by their effects on a protein called RhoB.

References:

Du, W., P.F. Lebowitz, and G.C. Prendergast. 1999. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Molecular and Cellular Biology 19(March).

Further Readings:

Fackelmann, K.A. 1997. Diverse strategies to vanquish cancer. Science News 151(May 3):274.

Sources:

George C. Prendergast
Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

From Science News, Vol. 155, No. 15, April 10, 1999, p. 239. Copyright © 1999, Science Service.

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