Therapy pits useful
gene against tumor
A cancer-suppressor gene called
p53, packaged in a disabled virus, temporarily thwarted tumor
growth in more than half of lung patients who received it.
Swisher, S.G., J.A. Roth, et al. 1999. Adenovirus-mediated
p53 gene transfer in advanced non-small-cell lung cancer. Journal
of the National Cancer Institute 91(May 5):763.
Larkin, M. 1996. Promising results reported for lung cancer gene
therapy. Lancet 348(Sept. 7):671.
Roth, J.A., et al. 1996. Retrovirus-mediated wild-type p53
gene transfer to tumors of patients with lung cancer. Nature Medicine
Skuse, G.R. 1995. Tumour suppressor genes in disease and therapy.
Lancet 345(April 8):902.
Travis, J. 1996. Putting a tumor suppressor back to work. Science
News 150(Aug. 31):134.
Jack A. Roth
University of Texas
M.D. Anderson Cancer Center
1515 Holcombe Boulevard
Houston, TX 77030
News, Vol. 155, No. 20, May 15, 1999, p. 310.
Copyright © 1999, Science Service.