Heavy
exposure to solvent linked to cancer
Exposure to the solvent trichloroethylene
increases the likelihood of a mutation at a key point in a gene suspected
to be a cancer suppressor.
References:
Brauch, H., et al. 1999. Trichloroethylene exposure and specific
somatic mutations in patients with renal cell carcinoma. Journal
of the National Cancer Institute 91(May 19):854.
Further Readings:
Glavac, D., et al. 1996. Mutations in the VHL tumor suppressor
gene and associated lesions in families with von Hippel-Lindau disease
from central Europe. Human Genetics 98:271.
Motzer, R.J., et al. 1996. Renal-cell carcinoma. New England
Journal of Medicine 335(Sept. 19):865.
Vamvakas, S., et al. 1998. Renal cell cancer correlated with
occupational exposure to trichloroethene. Journal of Cancer Research
and Clinical Oncology 124:374.
Additional information about trichloroethylene is available at http://www.atsdr.cdc.gov/ToxProfiles/phs8824.html,
http://ntp-server.niehs.nih.gov/htdocs/Lt-studies/about-abstracts.html,
and http://ntp-server.niehs.nih.gov/htdocs/LT-studies/tr273.html.
Sources:
Hiltrud Brauch
Fischer-Bosch-Institute of Clinical Pharmacology
Auerbachstrasse 112
70376 Stuttgart
Germany
Laura C. Green
Cambridge Environmental, Inc.
58 Charles Street, 3rd Floor
Cambridge, MA 02141
W. Marston Linehan
National Institutes of Health
National Cancer Institute
Building 10, Room 2B47
Bethesda, MD 20892-1501
Steven R. Tannenbaum
Massachusetts Institute of Technology
Room 56-731
Cambridge, MA 02139
From Science
News, Vol. 155, No. 22, May 29, 1999, p. 343.
Copyright © 1999, Science Service.
