I experienced cognitive dissonance while contemplating "Common
pollutants undermine masculinity" (SN: 4/3/99, p. 213).
If one-fifth to one gram of DEHP per kilogram is given to rats,
then a 50 kg (110 lb.) human should receive 10 to 50 g of DEHP.
If that much DEHP leached out of a dialysis system or IV bag and
tubing, surely the whole apparatus would have disintegrated beforehand.
Where is the research that shows that DEHP even leaches out of
plastic in realistic solutions?
Michael Clover
Los Alamos, N.M.
According to the Chemical Manufacturers Association's Phthalate
Esters Panel, "We are aware that some flexible vinyl medical
devices allow phthalate esters to enter a patient's blood stream.
... Probably the most common potential for exposure occurs when
patients receive fluidsnutrients, whole blood or blood components
intravenouslyfrom flexible vinyl bags or containers."
How close are human exposures to those producing toxicity
in animals? In addition to the assertions on this question by
Ted Schettler in the story, phthalate toxicologist L. Earl Gray
says that some rats showing testes damage in experiments "had
[DEHP] serum levels not too different from the dialysis patients."
J. Raloff