Rooting out dormant
HIV-infected cells
The immune protein interleukin-2,
coupled with standard anti-AIDS drugs, appears to flush immune cells
harboring latent HIV out of hiding and open the virus to attack.
References:
Chun, T.-W., et al. 1999. Effect of interleukin-2 on the pool of
latently infected, resting CD4+T cells in
HIV-1 infected patients receiving highly active anti-retroviral therapy.
Nature Medicine 5(June):651.
Further Readings:
Cohen, J. 1998. Exploring how to get at—and eradicate—hidden HIV.
Science 279:1854.
Cooper, D.A., and S. Emery. 1999. Latent reservoirs of HIV infection:
Flushing with IL-2? Nature Medicine 5(June):611.
Furtado, M.R., et al. 1999. Persistence of HIV-1 transcription
in peripheral-blood mononuclear cells in patients receiving potent
antiretroviral therapy. New England Journal of Medicine 340(May
27):1614.
Ho, D.D., et al. 1995. Rapid turnover of plasma virions and
CD4 lymphocytes in HIV-1 infection. Nature 373(Jan. 12):123.
Kovacs, J.A., et al. 1996. Controlled trial of interleukin-2
infusions in patients infected with the human immunodeficiency virus.
New England Journal of Medicine 335(Oct. 31):1350.
Kovacs, J.A., et al. 1995. Increases in CD4 T lymphocytes
with intermittent courses of interleukin-2 in patients with human
immunodeficiency virus infection. New England Journal of Medicine
332(March 2):567.
Pomerantz, R.J. 1999. Residual HIV-1 disease in the era of highly
active antiretroviral therapy. New England Journal of Medicine
340(May 27):1672.
Seppa, N. 1998. Blood, semen harbor distinct HIV mutations. Science
News 154(Oct. 31):279.
Zhang, L., et al. 1999. Quantifying residual HIV-1 replication
in patients receiving combination antiretroviral therapy. New England
Journal of Medicine 340(May 27):1605.
Sources:
Tae-Wook Chun
National Institutes of Health
National Institute of Allergy and Infectious Diseases
Building 10, Room 6A32
10 Center Drive
Bethesda, MD 20892
Warner C. Greene
University of California, San Francisco
Gladstone Institute of Virology and Immunology
P.O. Box 419100
San Francisco, CA 94141
Roger J. Pomerantz
Thomas Jefferson University
1020 Locust Street
Suite 329
Philadelphia, PA 19107
From Science
News, Vol. 155, No. 23, June 5, 1999, p. 359.
Copyright © 1999, Science Service.
