References & Sources

Synthetic drug slows glaucoma in rats

A synthetic drug that neutralizes an enzyme slows nerve damage in the eyes of rats with glaucoma.

References:

Neufeld, A.H., A. Sawada, and B. Becker. 1999. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proceedings of the National Academy of Sciences 96(Aug. 17):96.

Further Readings:

Corbett, J.A., et al. 1992. Diabetes 41:552.

D’Amico, D.J. 1994. Diseases of the retina. New England Journal of Medicine 331(July 14):95.

Di Polo, A., et al. 1998. Proceedings of the National Academy of Sciences 95:3978.

Grierson, I. 1996. Glaucoma and nitric oxide. Lancet 347(June 29):1781.

Kaufman, P.L. 1999. Nitric-oxide synthase and neurodegeneration/neuroprotection. Proceedings of the National Academy of Sciences 96(Aug. 17):9455.

Tielsch, J.M., et al. 1991. Journal of the American Medical Association 266:369.

Sources:

Paul L. Kaufman
University of Wisconsin-Madison
Department of Ophthalmology and Visual Sciences
Clinical Science Center
600 Highland Avenue
Madison, WI 53792-3220

Carl Kupfer
National Institutes of Health
National Eye Institute
31 Center Drive
Building 31, Room 6A03
Mailstop Code 2510
Bethesda, MD 20892-2510

Arthur H. Neufeld
Washington University
Department of Ophthalmology and Visual Sciences
Box 8096
660 South Euclid Avenue
St. Louis, MO 63110

From Science News, Vol. 156, No. 8, August 21, 1999, p. 119. Copyright © 1999, Science Service.