The dose required to kill 50 percent of target molecules is 1 (dotted line) for both of these hypothetical HIV drugs. But the steeper slope of the red drug reveals that a very small increase in dose can have a big effect on response. Drugs that attack HIV at points in the virus’s life cycle that involve many molecules have these steep slopes, new research shows.
Credit: C. Bickel/Science © 2011 AAAS
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