Leslie Gordon’s research team has shown that the genetic mutation that causes progeria disrupts a protein important in shaping a cell’s nucleus. This change leads to distortions in cell shape. A drug known as a farnesyltransferase inhibitor, or FTI, restored the normal appearance of cells in lab studies (above) and improved weight gain and artery health in children in a clinical trial.
Credit: B. Capell et al/PNAS 2005
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