Among other concerns, PPIs have been linked to infection with the bacterium Clostridium difficile. In one hospital, a team identified 138 patients with C. difficile. Of these, 88 were on a PPI, though only 34 had a clear medical reason for taking the reflux drug.
Credit: T. Dubé; Source: M.N. Choudhry et al/QJM 2008
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