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Web edition: July 6, 2012
Print edition: July 28, 2012; Vol.182 #2 (p. 18)
Glow-in-the-dark bacteria living in nematode worms flip a genetic switch to change from peaceful cohabitants into killers.
The M-form (M for mutualism) of Photorhabdus luminescens bacteria make friendly colonies inside nematodes. But the microbes switch to the deadly toxin-producing P-form (P for pathogenic) when their hosts are ready to eat an insect from the inside out. Worms vomit up the bacteria into insects, and the bacterial toxins kill and help digest the feast.
The transformation between mild-mannered and killer forms depends on the orientation of a piece of DNA called the madswitch promoter, Harvard University researchers report in the July 6 Science. In the “on” direction, madswitch turns on genes needed for the bacteria to live inside worms and damps down production of substances that help kill insects. Bacteria with the promoter in the “off” direction are the killer type.
Citations
V. S. Somvanshi et al. A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Science Vol. 337, July 6, 2012, p. 88. doi: 10.1126/science.1216641 [Go to]
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We have numerous bacteria on our skin all through our lives that prove incredibly damaging when they get into the blood stream. I wonder if a switch is flipped which causes the bacteria to change into a pathogen or it is just a switch of environment which allows the damage to occur.
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