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2013 American Association for Cancer Research meeting

Highlights from the annual AACR meeting, Washington, D.C., April 6-10, 2013

12:32pm, April 10, 2013

Excessive ovulation tied to cancer risk
Women who undergo many ovulatory cycles in a lifetime might be at increased risk of ovarian cancer, an analysis has found. The “incessant ovulation” hypothesis, which scientists proposed decades ago, holds that undergoing many cycles might increase cancer risk through high estrogen levels, more mutations in cells that line the ovaries or more shedding and regrowth of the uterine lining. But the hypothesis remains controversial. Epidemiologist Hannah Yang of the National Cancer Institute and her colleagues analyzed data  on the number of ovulatory cycles in nearly 800 women in Warsaw and Lodz, Poland, from 2001 to 2003. Cycle numbers were estimated by assessing age at first period, age at menopause, total time pregnant, duration of breastfeeding, use of oral contraceptives and other factors. The women had roughly 200 to 600 ovulatory cycles in a lifetime, Yang said. When she and her colleagues divided the

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