50 years ago, diabetic mice offered hope for understanding human disease | Science News



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50 Years Ago

50 years ago, diabetic mice offered hope for understanding human disease

Excerpt from the August 12, 1967 issue of Science News

7:00am, July 27, 2017
diabetic mice

MOUSE GUIDES Diabetic mice with mutations in the leptin receptor gene grow much larger and fatter (left) than mice that don’t have the mutations (right). These diabetic, or db/db, mice were first described 50 years ago and have been helping scientists study the disease ever since.

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Hope from diabetic mice

[Millions of diabetics] could be indebted to a strain of diabetic mice being bred in Bar Harbor, Maine. In diabetes research, “this mouse is the best working model to date,” one of its discoverers, Dr. Katharine P. Hummel, says.… A satisfactory animal subject had eluded diabetes researchers, until the mouse was found. — Science News, August 12, 1967


Hummel’s diabetic mice are still used in research to mimic type 2 diabetes in humans, which is linked to obesity. In the mid-1990s, researchers found that the diabetic mice carry a mutation in the leptin receptor gene, which prevents the hormone leptin from signaling fullness and triggering other metabolic processes. In people, however, the disease is more complicated. More than 40 genetic variants are associated with susceptibility to type 2 diabetes. Unlike the mouse mutation, none of those variants guarantee a person will develop the disease.


Science News Staff. Hope from diabetic mice. Science News. Vol. 92, August 12, 1967, p. 154.

S.C. Chua Jr. et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. Vol. 271, February 16, 1996, p. 994. doi: 10.1126/science.271.5251.994.

H. Chen et al. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell. Vol. 84, February 9, 1996, p. 491. doi: 10.1016/S0092-8674(00)81294-5.

L.A. Tartaglia et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. Vol. 83, December 29, 1995, p. 1263.  doi: 10.1016/0092-8674(95)90151-5.

Further Reading

B. Brookshire. The need to feed and eating for pleasure are inextricably linked. Science News Online, August 27, 2015.

T.H. Saey. Gene variant tied to diabetes in Greenlanders. Science News Online, June 18, 2014.

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