Disabling enzyme could block Zika | Science News

ADVERTISEMENT

SUPPORT SCIENCE NEWS

Science News is a nonprofit.

Help us keep you informed.


News in Brief

Disabling enzyme could block Zika

By
4:17pm, December 13, 2016

SAN FRANCISCO — Disrupting the Zika enzyme NS3 could help stop the virus. NS3 causes problems when it gloms on to centrioles, structures inside cells needed to divvy up chromosomes when cells divide, Andrew Kodani, a cell biologist at Boston Children’s Hospital, reported December 6 at the American Society for Cell Biology’s annual meeting.

Zika, dengue and other related viruses, known as flaviviruses, all use a version of NS3 to chop joined proteins apart so they can do their jobs. (Before chopping, Zika’s 10 proteins are made as one long protein.) But once NS3 finishes slicing virus proteins, it moves to the centrioles and can interfere with their assembly, Kodani and colleagues found.

This article is only available to Science News subscribers. Already a subscriber? Log in now. Or subscribe today for full access.

Get Science News headlines by e-mail.

More Genes & Cells articles

From the Nature Index Paid Content