Suppressing stomach acid while taking antibiotics may allow antibiotic-resistant bacteria to colonize the intestines, a study shows.
Researchers had previously linked stomach-acid suppression to pneumonia (SN: 10/30/04, p. 277: Available to subscribers at Affairs of the Heartburn: Drugs for stomach acid may hike pneumonia risk). To test the effect of acid-suppressing drugs on bacteria passing through the stomach to the intestines, researchers gave mice two kinds of live, resistant bacteria via a feeding tube over 3 days. The animals then received an acid-suppressing drug, the antibiotic clindamycin, or both. The acid blocker was a proton-pump inhibitor called pantoprazole.