Latest Issue of Science News


News

Drug breaks up Alzheimer’s-like deposits in mice

Failed human trials of similar approach fuel skepticism

A new therapy busts up deposits of sticky plaques associated with Alzheimer’s disease in the brains of mice. Further tests with the experimental drug could help settle the question of how important the plaques are to the disease, and might even lead to a treatment for its most advanced stages.

The study, described in the Dec. 6 Neuron, tested an antibody called mE8 in the brains of older mice that had been genetically altered to accumulate amyloid-beta, a protein that forms plaques in the brains of people with Alzheimer’s. “We removed 50 percent of the plaque,” says study coauthor Ronald DeMattos of Eli Lilly and Co. in Indianapolis. “This is a big deal.”

Note: To comment, Science News subscribing members must now establish a separate login relationship with Disqus. Click the Disqus icon below, enter your e-mail and click “forgot password” to reset your password. You may also log into Disqus using Facebook, Twitter or Google.

X
This article is available only to subscribing members. Join SSP today or Log in.